Mitochondrial protein processing

Across TCGA cell cohorts, RNA activity of the Mitochondrial protein processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HCC1, CCNG1, and ITGB1BP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial protein processing activity versus R3HCC1 in BLOOD_Myeloma (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	R3HCC1 →	-0.902	-0.178	.006	.001	3	5
BLOOD_Myeloma	CCNG1 →	-1.388	-0.172	.001	.001	3	4
LARGE_INTESTINE	ITGB1BP1 →	-0.667	-0.104	.004	.008	3	4
PANCREAS	NDUFV2 →	+1.140	+0.205	<.001	.009	3	4
CNS	ANKRD13A →	-1.036	-0.158	.001	.002	3	4
STOMACH	SPIRE1 →	+2.808	+0.138	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034982 vs R3HCC1 — BLOOD_Myeloma

Explore this scatter interactively →