Response to histamine

Across TCGA patient cohorts, RNA activity of the Response to histamine pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HTATIP2, LACTB2, and AOC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to histamine activity versus HTATIP2 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HTATIP2 →	+0.434	+0.109	<.001	.001	3	6
UCEC	LACTB2 →	+0.403	+0.139	<.001	.004	3	6
UCEC	AOC1 →	+0.967	+0.159	<.001	<.001	3	6
LSCC	TDRD7 →	+0.200	+0.070	.001	<.001	3	6
HNSC	LAD1 →	+0.524	+0.101	.001	<.001	2	6
HNSC	PLCB3 →	+0.262	+0.134	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034776 vs HTATIP2 — LUAD

Explore this scatter interactively →