Response to histamine

Across TCGA pan-cancer cohorts, RNA activity of the Response to histamine pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Response to histamine pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and LGG, show the opposite pattern, with higher activity associated with better survival.

PAAD, KIRC, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.279	0.471	<.001	66	view →
KIRC	DFS	Quartile	IV	0.366	0.633	.002	48	view →
BLCA	OS	Tertile	IV	0.593	0.158	.001	34	view →
LGG	OS	Median	All	0.534	0.363	<.001	33	view →
ACC	DFS	Median	All	0.534	0.872	.001	30	view →
ESCA	OS	Tertile	II,III,IV	0.398	0.630	.010	30	view →
STAD	DFS	Median	IV	0.195	0.528	.004	27	view →
CESC	OS	Tertile	IV	0.277	0.735	.003	24	view →
KIRP	OS	Quartile	All	0.990	0.893	.002	23	view →
LIHC	OS	Median	All	0.828	0.726	.007	20	view →
LUAD	OS	Tertile	II,III,IV	0.654	0.839	.006	15	view →
PRAD	DFS	Quartile	All	0.958	0.910	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0034776–PAAD (OS)

Open the PAAD breakdown →