Response to histamine

Across TCGA patient cohorts, RNA activity of the Response to histamine pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREML4, MEFV, and G0S2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to histamine activity versus TREML4 in UCEC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TREML4 →	+0.374	+0.570	.001	.002	3	6
LSCC	MEFV →	+0.667	+0.553	<.001	<.001	3	5
LSCC	G0S2 →	+0.958	+0.518	<.001	<.001	3	5
LSCC	APOBEC3A →	+0.756	+0.408	.001	.007	3	5
LUAD	FCGR3B →	+1.366	+0.583	<.001	.002	3	5
LSCC	CXCR1 →	+1.026	+0.628	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034776 vs TREML4 — UCEC

Explore this scatter interactively →