Response to histamine

Across TCGA patient cohorts, RNA activity of the Response to histamine pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RETN, S100A12, and BPI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to histamine activity versus RETN in LSCC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RETN →	+1.088	+0.721	<.001	<.001	3	6
LSCC	S100A12 →	+1.219	+0.661	<.001	<.001	3	6
LSCC	BPI →	+1.136	+0.632	<.001	<.001	3	6
COAD	CAMP →	+1.617	+0.828	<.001	<.001	3	6
COAD	ITGAM →	+0.769	+0.767	<.001	<.001	3	6
PDAC	MMP9 →	+1.219	+0.925	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034776 vs RETN — LSCC

Explore this scatter interactively →