Response to histamine

Across TCGA cell cohorts, RNA activity of the Response to histamine pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSTB, C20orf144, and DAG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSTB grouped by Response to histamine-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSTB →	-1.069	-0.923	.001	.003	3	4
CNS	C20orf144 →	-0.198	-0.836	.001	.009	3	4
BLOOD_Leukemia	DAG1 →	-0.954	-1.258	.003	.002	3	3
KIDNEY	CTDSPL →	-1.035	-1.246	.005	.001	3	3
BLOOD_Lymphoma	PTDSS1 →	-0.866	-2.345	.008	.001	3	3
SKIN	TBCB →	-0.492	-1.293	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSTB by Response to histamine activity — SKIN

Explore this box plot interactively →