Negative regulation of monoatomic ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of monoatomic ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, DDX47, and PRKG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic ion transmembrane transport activity versus SEPTIN4 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	+0.647	+0.033	<.001	.003	3	7
LSCC	DDX47 →	-0.356	-0.040	<.001	<.001	3	6
HNSC	PRKG1 →	+0.385	+0.038	<.001	.004	3	6
BRCA	NAT10 →	-0.366	-0.036	.001	<.001	3	6
GBM	NUP107 →	-0.181	-0.036	<.001	<.001	3	6
COAD	RRP36_S73 →	-0.521	-0.027	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034766 vs SEPTIN4 — GBM

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