Negative regulation of monoatomic ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of monoatomic ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM124A, ANKDD1B, and E2F3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic ion transmembrane transport activity versus FAM124A in UCEC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM124A →	-0.744	-0.194	.003	.003	3	5
LUAD	ANKDD1B →	+1.041	+0.182	<.001	.004	3	5
BRCA	E2F3 →	-0.417	-0.084	.003	.008	3	5
BRCA	FAM72D →	-0.699	-0.144	<.001	<.001	3	5
BRCA	MCM3 →	-0.705	-0.188	<.001	<.001	3	4
BRCA	FBXO5 →	-0.717	-0.145	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034766 vs FAM124A — UCEC

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