Negative regulation of monoatomic ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of monoatomic ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2D, STK39, and LRFN1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic ion transmembrane transport activity versus CAMK2D in BONE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAMK2D →	+1.849	+0.096	<.001	<.001	3	13
OESOPHAGUS	STK39 →	+1.821	+0.090	.002	.002	3	12
BONE	LRFN1 →	-1.134	-0.112	<.001	.003	2	11
BONE	FBF1 →	-1.405	-0.108	<.001	.003	3	10
BONE	SH3GLB1 →	+1.135	+0.099	<.001	<.001	3	9
SKIN	PPP3CA →	+0.927	+0.089	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034766 vs CAMK2D — BONE

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