Positive regulation of transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIN, COQ10A, and ZCCHC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIN grouped by Positive regulation of transmembrane transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KIN →	+0.761	+0.177	.001	.002	3	3
LARGE_INTESTINE	COQ10A →	+0.838	+0.171	<.001	.005	3	3
LARGE_INTESTINE	ZCCHC18 →	+0.748	+0.183	.002	.001	3	3
LARGE_INTESTINE	FAM50A →	+1.017	+0.189	<.001	.004	3	3
LARGE_INTESTINE	ATP5F1D →	-0.770	-0.195	.004	.007	2	4
UPPER_AERODIGESTIVE_TRACT	SPOCK1 →	-3.723	-0.254	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIN by Positive regulation of transmembrane transport activity — LIVER

Explore this box plot interactively →