Regulation of iron ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of iron ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADM, C1QTNF6, and RILPL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADM grouped by Regulation of iron ion transmembrane transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADM →	+3.815	+0.298	<.001	.002	3	3
LUNG_SCLC	C1QTNF6 →	+1.173	+0.296	.001	.001	3	3
LARGE_INTESTINE	RILPL2 →	-0.584	-0.710	<.001	.007	3	3
LUNG_NSCLC_LUSC	NPTN →	+0.631	+0.349	.005	.003	3	2
SOFT_TISSUE	ISYNA1 →	+4.211	+0.325	.002	.008	2	3
CNS	SPATA20 →	-0.972	-0.598	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADM by Regulation of iron ion transmembrane transport activity — SOFT_TISSUE

Explore this box plot interactively →