Piecemeal microautophagy of the nucleus

Across TCGA cell cohorts, RNA activity of the Piecemeal microautophagy of the nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YWHAE, B9D2, and USP25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YWHAE grouped by Piecemeal microautophagy of the nucleus-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	YWHAE →	+0.848	+1.090	.002	.006	3	3
KIDNEY	B9D2 →	-1.035	-1.382	.001	.001	3	3
STOMACH	USP25 →	+0.755	+0.939	.003	.006	3	3
BREAST	RBM14 →	-0.601	-0.658	.004	.003	3	3
SOFT_TISSUE	MID1IP1 →	+3.558	+1.273	<.001	.005	3	3
LARGE_INTESTINE	GLUL →	+1.813	+0.897	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YWHAE by Piecemeal microautophagy of the nucleus activity — LUNG_SCLC

Explore this box plot interactively →