Response to prostaglandin E

Across TCGA patient cohorts, RNA activity of the Response to prostaglandin E pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF831, SFRP1, and PTGER4, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin E activity versus ZNF831 in LAML (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	ZNF831 →	+0.902	+0.067	<.001	<.001	3	29
BRCA	SFRP1 →	+1.963	+0.044	<.001	<.001	3	28
SCLC	PTGER4 →	+1.254	+0.110	.001	<.001	3	28
DLBC	ABCD2 →	+1.282	+0.076	<.001	<.001	3	28
CHOL	GZMK →	+2.340	+0.063	<.001	<.001	3	27
MESO	TNFSF4 →	+1.758	+0.051	<.001	.004	2	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034695 vs ZNF831 — LAML

Explore this scatter interactively →