Response to prostaglandin E

Across TCGA patient cohorts, RNA activity of the Response to prostaglandin E pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZCCHC24, CNRIP1, and RCSD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin E activity versus ZCCHC24 in OV (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZCCHC24 →	+1.057	+0.086	<.001	<.001	3	10
UCEC	CNRIP1 →	+0.888	+0.070	<.001	<.001	3	10
UCEC	RCSD1 →	+0.692	+0.091	<.001	<.001	3	9
LSCC	SEPTIN1 →	+0.907	+0.098	<.001	<.001	3	9
LSCC	SEPTIN6 →	+0.581	+0.097	<.001	<.001	3	9
UCEC	SOD3 →	+1.018	+0.073	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034695 vs ZCCHC24 — OV

Explore this scatter interactively →