Response to prostaglandin E

Across TCGA patient cohorts, RNA activity of the Response to prostaglandin E pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF122, INPP5A, and SLC25A12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin E activity versus RNF122 in HNSC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF122 →	+0.414	+0.114	.003	.001	3	5
HNSC	INPP5A →	+0.512	+0.107	<.001	.002	3	4
HNSC	SLC25A12 →	+0.558	+0.150	.005	.001	3	3
HNSC	SPATA5 →	+0.450	+0.129	.005	.002	3	3
HNSC	IRAK1BP1 →	+0.384	+0.122	.008	<.001	3	3
GBM	C1orf115 →	+0.970	+0.132	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034695 vs RNF122 — HNSC

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