Response to prostaglandin E

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin E pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTP4A1, SLC35F5, and MTA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTP4A1 grouped by Response to prostaglandin E-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PTP4A1 →	-1.268	-1.149	.001	.005	3	4
OVARY	SLC35F5 →	-1.196	-1.246	<.001	<.001	3	4
LUNG_NSCLC_LUSC	MTA1 →	+0.978	+0.924	.001	.007	3	4
CNS	SRSF7 →	+0.301	+0.805	.009	.003	2	5
LUNG_NSCLC_LUAD	BTC →	-1.177	-0.592	<.001	.008	3	4
LUNG_NSCLC_LUSC	ITGA5 →	-3.191	-1.140	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTP4A1 by Response to prostaglandin E activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →