Response to prostaglandin E

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin E pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCN2, DDX17, and MYO5C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UCN2 grouped by Response to prostaglandin E-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UCN2 →	+0.185	+0.189	.001	.004	3	5
SOFT_TISSUE	DDX17 →	+0.330	+0.143	.002	.002	3	4
SOFT_TISSUE	MYO5C →	+0.230	+0.185	<.001	.002	3	4
SOFT_TISSUE	NPM1 →	+0.424	+0.174	<.001	.003	3	4
STOMACH	DTWD1 →	-0.248	-0.196	.003	.005	3	4
LUNG_SCLC	RNF11 →	-0.162	-0.141	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UCN2 by Response to prostaglandin E activity — SOFT_TISSUE

Explore this box plot interactively →