Response to prostaglandin E

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin E pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB4, ATP6AP2, and IFT140, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin E activity versus ZBTB4 in PANCREAS (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZBTB4 →	+1.052	+0.269	<.001	<.001	3	5
CNS	ATP6AP2 →	+0.822	+0.273	.005	.001	3	5
LIVER	IFT140 →	+0.589	+0.281	.006	.003	3	5
SOFT_TISSUE	UCK2 →	-0.707	-0.285	.008	.001	3	4
SOFT_TISSUE	GNL3L →	-1.025	-0.285	.006	.001	3	4
KIDNEY	TSNAXIP1 →	+0.738	+0.281	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034695 vs ZBTB4 — PANCREAS

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