Obsolete ncRNA catabolic process

pathway activity — cross-omics
GO:0034661Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete ncRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFWD3, SEPTIN4, and CDT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMRFWD3 →+0.308+0.122<.001.00136
GBMSEPTIN4 →-0.943-0.168<.001<.00136
BRCACDT1 →+0.659+0.107.009.00836
LSCCUNG →+0.504+0.149.009.00736
LSCCLMNB1 →+0.615+0.207<.001<.00135
CCRCCRACGAP1 →+0.356+0.112<.001.00735
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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