Cortisol metabolic process

Across TCGA patient cohorts, RNA activity of the Cortisol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLSCR2, TPT1P8, and CLYBL-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortisol metabolic process activity versus PLSCR2 in UCEC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLSCR2 →	-0.515	-0.525	.005	<.001	3	3
COAD	TPT1P8 →	-0.027	-0.746	.001	.002	3	3
COAD	CLYBL-AS1 →	+0.039	+0.899	.009	.009	2	4
CCRCC	FAM131B →	+0.315	+0.714	<.001	.001	2	4
LSCC	RCC1 →	-0.442	-0.380	.007	.006	3	3
BRCA	TRMT6 →	-0.410	-0.613	.003	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034650 vs PLSCR2 — UCEC

Explore this scatter interactively →