Cellular response to UV

Across TCGA patient cohorts, RNA activity of the Cellular response to UV pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIG1, E2F8, and MCM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to UV activity versus LIG1 in PDAC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LIG1 →	+0.310	+0.217	.004	<.001	3	5
BRCA	E2F8 →	+0.660	+0.115	<.001	.001	3	4
OV	MCM7 →	+0.744	+0.165	.001	.006	3	4
LUAD	CDT1 →	+0.832	+0.200	<.001	<.001	3	4
OV	MCM2 →	+0.874	+0.207	.006	.001	3	4
OV	UNG →	+0.595	+0.180	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034644 vs LIG1 — PDAC

Explore this scatter interactively →