Phosphatidylcholine catabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHA7, MLYCD, and NCL_S67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine catabolic process activity versus PLEKHA7 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLEKHA7 →	+0.303	+0.038	.005	<.001	3	6
LSCC	MLYCD →	+0.302	+0.052	<.001	.002	3	5
GBM	NCL_S67 →	-0.822	-0.077	<.001	<.001	3	5
COAD	RPP40 →	-0.317	-0.024	.001	.003	3	4
LUAD	FOXK1 →	-0.201	-0.036	<.001	.004	3	4
GBM	ARRB1 →	+0.317	+0.055	.006	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034638 vs PLEKHA7 — BRCA

Explore this scatter interactively →