Phosphatidylcholine catabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PAQR8, and DKK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine catabolic process activity versus PLA2G4A in HNSC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLA2G4A →	+1.415	+0.268	<.001	<.001	3	4
UCEC	PAQR8 →	+0.420	+0.148	.003	.002	3	3
PDAC	DKK4 →	+1.100	+0.198	.001	.001	3	3
LUAD	CXCR2 →	+0.445	+0.188	.003	.004	3	3
HNSC	MIR4429 →	-0.367	-0.180	.001	.003	3	3
PDAC	SRD5A3-AS1 →	+0.451	+0.187	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034638 vs PLA2G4A — HNSC

Explore this scatter interactively →