Phosphatidylcholine catabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHGA, CHRNA4, and XIAP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHGA grouped by Phosphatidylcholine catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHGA →	-0.337	-1.643	.001	.008	2	2
LARGE_INTESTINE	CHRNA4 →	+0.272	+2.184	.009	.001	3	1
LARGE_INTESTINE	XIAP →	-0.229	-2.160	.006	<.001	3	1
LARGE_INTESTINE	UBXN8 →	+0.193	+2.166	.008	<.001	3	1
LARGE_INTESTINE	CCDC47 →	+0.253	+2.214	.003	<.001	3	1
LARGE_INTESTINE	C9 →	+0.303	+2.166	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHGA by Phosphatidylcholine catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →