Cellular response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Cellular response to oxidative stress pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, SEPTIN4_S432, and SYNPO, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxidative stress activity versus PRKG1 in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRKG1 →	+0.561	+0.048	<.001	<.001	3	9
HNSC	SEPTIN4_S432 →	+0.632	+0.045	<.001	.004	3	8
BRCA	SYNPO →	+0.383	+0.028	<.001	<.001	3	8
CCRCC	DCN →	+0.998	+0.026	<.001	<.001	3	8
BRCA	LUM →	+0.814	+0.028	<.001	<.001	3	8
PDAC	PPM1F →	+0.234	+0.020	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034599 vs PRKG1 — LSCC

Explore this scatter interactively →