Cellular response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Cellular response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMR1, PLEKHA8, and GBP3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxidative stress activity versus FMR1 in COAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FMR1 →	+0.478	+0.266	.004	.002	3	1
COAD	PLEKHA8 →	+0.435	+0.272	.002	.001	3	1
COAD	GBP3 →	-1.080	-0.295	.001	.005	3	1
COAD	PFKFB2 →	-0.979	-0.300	.001	<.001	3	1
COAD	APC →	-0.382	-0.299	<.001	<.001	3	1
COAD	CAMK2D →	-0.809	-0.299	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034599 vs FMR1 — COAD

Explore this scatter interactively →