piRNA processing

Across TCGA patient cohorts, RNA activity of the piRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP9Y, UBE2SP2, and CCM2L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, piRNA processing activity versus USP9Y in HNSC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	USP9Y →	-0.966	-0.396	.003	.009	3	3
BRCA	UBE2SP2 →	-1.569	-0.901	<.001	<.001	3	3
PDAC	CCM2L →	-0.177	-0.257	.006	<.001	3	3
BRCA	NOVA2 →	-0.227	-0.560	.002	.007	3	3
PDAC	LRRC36 →	-0.277	-0.254	.005	<.001	3	3
UCEC	PALD1 →	-0.880	-0.280	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034587 vs USP9Y — HNSC

Explore this scatter interactively →