piRNA processing

Across TCGA cell cohorts, RNA activity of the piRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDZD2, HMG20A, and TTC21B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDZD2 grouped by piRNA processing-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PDZD2 →	+1.911	+1.051	.003	.004	3	5
BLOOD_Myeloma	HMG20A →	+0.807	+1.648	.007	<.001	3	4
BLOOD_Leukemia	TTC21B →	+0.651	+0.947	<.001	.008	2	5
CNS	PKN2 →	+0.484	+0.955	.002	.002	3	4
BLOOD_Myeloma	SLC35F5 →	+1.128	+1.372	.008	.002	3	3
BLOOD_Myeloma	ZCCHC17 →	+0.772	+1.086	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDZD2 by piRNA processing activity — SOFT_TISSUE

Explore this box plot interactively →