piRNA processing

Across TCGA cell cohorts, RNA activity of the piRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTSF1, NUP50, and TPD52L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, piRNA processing activity versus GTSF1 in BLOOD_Leukemia (Pearson r = 0.88).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GTSF1 →	+3.306	+2.137	.001	<.001	3	3
BLOOD_Lymphoma	NUP50 →	+0.589	+1.295	.001	.004	3	2
LUNG_SCLC	TPD52L1 →	-1.539	-1.784	.003	<.001	3	1
LUNG_SCLC	IL18R1 →	+1.069	+1.222	.006	.006	3	1
LUNG_SCLC	AARS2 →	+0.948	+1.307	.003	.002	3	1
LUNG_SCLC	RAB25 →	+1.530	+1.617	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034587 vs GTSF1 — BLOOD_Leukemia

Explore this scatter interactively →