Early endosome to Golgi transport

Across TCGA cell cohorts, RNA activity of the Early endosome to Golgi transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DESI2, NUP205, and GON7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Early endosome to Golgi transport activity versus DESI2 in BLOOD_Leukemia (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DESI2 →	-0.758	-0.655	<.001	.002	3	4
BLOOD_Leukemia	NUP205 →	-0.547	-0.633	.001	.003	3	4
BONE	GON7 →	+1.180	+2.056	<.001	<.001	3	3
BONE	FAM228B →	-1.361	-1.639	.001	.002	3	3
URINARY_TRACT	XPR1 →	-0.666	-0.271	.001	.002	3	3
URINARY_TRACT	FAM160B2 →	-0.806	-0.271	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034498 vs DESI2 — BLOOD_Leukemia

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