Protein localization to phagophore assembly site

Across TCGA patient cohorts, RNA activity of the Protein localization to phagophore assembly site pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALM, CDCP1, and DNAJC7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to phagophore assembly site activity versus PALM in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PALM →	+0.511	+0.030	<.001	<.001	3	6
LUAD	CDCP1 →	-0.366	-0.034	.006	.005	3	6
BRCA	DNAJC7 →	-0.264	-0.042	<.001	<.001	3	5
BRCA	RPL5 →	-0.194	-0.040	<.001	<.001	3	5
CCRCC	RPS2 →	-0.231	-0.055	.005	<.001	3	5
LUAD	RPS6KA5 →	+0.371	+0.040	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034497 vs PALM — BRCA

Explore this scatter interactively →