Protein localization to phagophore assembly site

Across TCGA patient cohorts, RNA activity of the Protein localization to phagophore assembly site pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM4, NCF1, and AZGP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to phagophore assembly site activity versus CEACAM4 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEACAM4 →	-0.572	-0.300	<.001	<.001	3	4
BRCA	NCF1 →	-0.840	-0.285	<.001	<.001	3	4
LUAD	AZGP1 →	+2.600	+0.179	<.001	.003	3	4
BRCA	GNPTG →	+0.546	+0.196	.002	.004	3	4
BRCA	GPR25 →	-0.356	-0.203	<.001	.002	3	4
LUAD	GLTP →	+0.326	+0.163	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034497 vs CEACAM4 — BRCA

Explore this scatter interactively →