Very-low-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Very-low-density lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAX, PARVG, and PSAP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very-low-density lipoprotein particle clearance activity versus ITGAX in PDAC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ITGAX →	+0.575	+0.102	<.001	<.001	3	8
UCEC	PARVG →	+0.389	+0.111	<.001	.003	3	8
LSCC	PSAP →	+0.373	+0.093	<.001	<.001	3	7
LSCC	EVL →	+0.494	+0.073	.002	.004	3	6
UCEC	IFI30 →	+0.609	+0.133	.002	.005	2	7
PDAC	ITGB2 →	+0.506	+0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034447 vs ITGAX — PDAC

Explore this scatter interactively →