Lipid oxidation

Across TCGA patient cohorts, RNA activity of the Lipid oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BDH2, NCL_S67, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid oxidation activity versus BDH2 in LUAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BDH2 →	+0.633	+0.042	<.001	<.001	3	10
GBM	NCL_S67 →	-0.945	-0.047	<.001	<.001	3	9
GBM	SMC4 →	-0.488	-0.034	<.001	<.001	3	8
LUAD	SPTBN1 →	+0.233	+0.027	<.001	<.001	3	8
BRCA	ADD1 →	+0.261	+0.022	<.001	<.001	3	8
COAD	CRYL1 →	+0.432	+0.021	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034440 vs BDH2 — LUAD

Explore this scatter interactively →