Response to fluid shear stress

Across TCGA patient cohorts, RNA activity of the Response to fluid shear stress pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, TLN1, and CAVIN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fluid shear stress activity versus SYNPO2 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SYNPO2 →	+0.703	+0.054	.003	.002	3	10
GBM	TLN1 →	+0.365	+0.068	<.001	<.001	3	10
BRCA	CAVIN1 →	+0.784	+0.034	<.001	<.001	3	10
BRCA	KANK2 →	+0.613	+0.045	<.001	<.001	3	10
GBM	DCN →	+1.088	+0.069	<.001	<.001	3	10
OV	PPM1F →	+0.255	+0.054	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034405 vs SYNPO2 — CCRCC

Explore this scatter interactively →