Telomere tethering at nuclear periphery

Across TCGA patient cohorts, RNA activity of the Telomere tethering at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HJURP, ORC5, and PBK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere tethering at nuclear periphery activity versus HJURP in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HJURP →	+0.798	+0.556	<.001	<.001	3	4
LSCC	ORC5 →	+0.526	+0.429	<.001	.007	3	4
HNSC	PBK →	+0.860	+0.539	.001	.003	3	4
HNSC	RNU7-75P →	+1.015	+0.776	.002	<.001	3	4
LSCC	HROB →	+0.543	+0.428	.002	.004	3	4
PDAC	KIF2C →	+0.546	+0.493	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034398 vs HJURP — LSCC

Explore this scatter interactively →