Protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM24, LIMK2, and GNAI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM24 grouped by Protein localization to cell surface-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBM24 →	-2.026	-0.442	<.001	.006	3	4
BLOOD_Myeloma	LIMK2 →	+1.334	+0.475	.009	.001	3	4
KIDNEY	GNAI1 →	-1.320	-1.417	.007	.002	3	3
BREAST	ZNF710 →	+1.142	+0.733	<.001	.002	3	3
LIVER	WNK2 →	+3.541	+0.572	.003	.004	2	4
BREAST	C15orf39 →	+0.707	+0.654	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM24 by Protein localization to cell surface activity — LIVER

Explore this box plot interactively →