Positive regulation of smooth muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of smooth muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2A, CDKN2A-DT, and PABPC1P8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell apoptotic process activity versus CDKN2A in OV (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDKN2A →	+2.025	+0.167	<.001	<.001	3	3
GBM	CDKN2A-DT →	+0.890	+0.161	<.001	.002	3	3
LSCC	PABPC1P8 →	+0.015	+0.278	.007	.003	3	3
PDAC	OR2W3 →	+0.124	+0.188	<.001	<.001	3	3
LUAD	MIR589 →	-0.592	-0.131	<.001	.007	3	2
LUAD	LINC01691 →	-0.298	-0.146	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034393 vs CDKN2A — OV

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