Negative regulation of smooth muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of smooth muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCLY, SIPA1L2_S148, and SLC2A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell apoptotic process activity versus SCLY in BRCA (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCLY →	-0.406	-0.066	<.001	<.001	3	5
LSCC	SIPA1L2_S148 →	+0.579	+0.097	<.001	<.001	3	5
LSCC	SLC2A1 →	+0.638	+0.091	<.001	<.001	3	5
LSCC	SLC3A2 →	+0.484	+0.086	<.001	<.001	3	5
LSCC	SMC2 →	+0.437	+0.106	<.001	<.001	3	5
UCEC	TFRC →	+0.650	+0.105	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034392 vs SCLY — BRCA

Explore this scatter interactively →