Negative regulation of smooth muscle cell apoptotic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of smooth muscle cell apoptotic process pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Negative regulation of smooth muscle cell apoptotic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUSC, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRP, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.760	0.634	<.001	112	view →
KIRP	DFS	Median	All	0.498	0.677	<.001	108	view →
ACC	DFS	Quartile	All	0.316	0.803	<.001	57	view →
SKCM	OS	Median	All	0.251	0.399	<.001	53	view →
OV	DFS	Median	All	0.333	0.422	.005	52	view →
COAD	DFS	Quartile	II,III,IV	0.438	0.801	<.001	30	view →
LUAD	DFS	Median	All	0.591	0.749	<.001	30	view →
LUSC	DFS	Quartile	All	0.824	0.681	<.001	29	view →
PAAD	OS	Tertile	II,III,IV	0.662	0.396	.001	28	view →
KICH	OS	Median	II,III,IV	0.520	1.000	.008	25	view →
LAML	DFS	Median	All	0.468	0.285	.008	24	view →
UCEC	DFS	Quartile	All	0.637	0.770	.021	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0034392–HNSC (DFS)

Open the HNSC breakdown →