Negative regulation of smooth muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP3, GRIN1, and RPS4X, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQGAP3 grouped by Negative regulation of smooth muscle cell apoptotic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQGAP3 →	-0.151	-0.145	.001	.006	3	5
LUNG_NSCLC_LUSC	GRIN1 →	-0.242	-0.169	.006	.001	3	4
BREAST	RPS4X →	+0.382	+0.098	.001	.003	3	4
LUNG_NSCLC_LUSC	TFPI →	+0.168	+0.126	.001	.001	3	4
BLOOD_Leukemia	LONRF1 →	+0.190	+0.075	.007	.004	3	4
SKIN	TGFBR1 →	-0.089	-0.097	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQGAP3 by Negative regulation of smooth muscle cell apoptotic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →