Negative regulation of smooth muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAT10, PPAN, and RPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell apoptotic process activity versus NAT10 in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NAT10 →	+1.022	+0.300	.006	.005	3	6
LARGE_INTESTINE	PPAN →	+0.550	+0.219	.002	.002	3	6
CNS	RPS2 →	+0.984	+0.299	<.001	<.001	3	6
BONE	DNMT1 →	+0.871	+0.293	.008	.007	3	5
BONE	NOLC1 →	+0.884	+0.324	.002	.002	3	5
BONE	TUFM →	+0.698	+0.389	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034392 vs NAT10 — BONE

Explore this scatter interactively →