High-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the High-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREM2, NKTR, and BRCA1P1, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle clearance activity versus TREM2 in SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	TREM2 →	+2.049	+0.272	<.001	<.001	3	25
DLBC	NKTR →	-1.412	-0.104	<.001	<.001	3	24
DLBC	BRCA1P1 →	-2.004	-0.097	<.001	<.001	3	24
UVM	PNN →	-1.135	-0.068	<.001	<.001	3	24
DLBC	CCDC66 →	-0.853	-0.085	<.001	<.001	3	24
UVM	PRPF39 →	-1.241	-0.068	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034384 vs TREM2 — SCLC

Explore this scatter interactively →