High-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the High-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RACK1, RRAS2, and PIGB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RACK1 grouped by High-density lipoprotein particle clearance-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RACK1 →	-0.535	-1.346	.003	.009	3	5
CNS	RRAS2 →	-1.482	-0.976	<.001	.005	3	4
BREAST	PIGB →	+0.499	+1.104	.001	<.001	3	4
SKIN	NAP1L5 →	+1.442	+0.972	.005	.006	3	4
BLOOD_Leukemia	SLC9A8 →	+0.748	+1.349	.006	.001	3	4
CNS	NINL →	+2.180	+1.143	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RACK1 by High-density lipoprotein particle clearance activity — KIDNEY

Explore this box plot interactively →