High-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the High-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB1, MAOA, and PDGFC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle clearance activity versus SCARB1 in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCARB1 →	+2.198	+0.830	<.001	.008	3	4
PANCREAS	MAOA →	+2.121	+1.096	.001	.005	3	4
BONE	PDGFC →	+2.390	+1.508	<.001	<.001	3	4
BLOOD_Lymphoma	VTI1B →	-0.587	-0.997	.001	.002	3	3
BLOOD_Lymphoma	MAPK3 →	-0.967	-0.986	.006	<.001	3	3
LUNG_NSCLC_LUSC	ASAH1 →	-1.660	-1.582	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034384 vs SCARB1 — SKIN

Explore this scatter interactively →