Low-density lipoprotein particle remodeling

Across TCGA patient cohorts, RNA activity of the Low-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CR1, MEDAG, and PTGIS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Low-density lipoprotein particle remodeling activity versus CR1 in GBM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CR1 →	+0.760	+0.193	<.001	<.001	3	8
OV	MEDAG →	+1.413	+0.162	<.001	.004	3	7
OV	PTGIS →	+1.883	+0.297	<.001	<.001	3	7
OV	PLA2G2A →	+2.124	+0.296	<.001	<.001	3	7
BRCA	ACKR1 →	+1.480	+0.196	<.001	<.001	3	7
OV	CD93 →	+0.988	+0.230	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034374 vs CR1 — GBM

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