Low-density lipoprotein particle remodeling

Across TCGA pan-cancer cohorts, RNA activity of the Low-density lipoprotein particle remodeling pathway is associated with patient survival in 29 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Low-density lipoprotein particle remodeling pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and PAAD, show the opposite pattern, with higher activity associated with better survival.

COAD, PAAD, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.759	0.470	<.001	86	view →
PAAD	OS	Median	All	0.520	0.282	<.001	75	view →
OV	DFS	Median	III,IV	0.486	0.570	.006	60	view →
STAD	OS	Quartile	All	0.447	0.705	<.001	48	view →
UCS	OS	Quartile	II,III,IV	0.140	0.540	.023	42	view →
BLCA	DFS	Quartile	All	0.582	0.177	.004	39	view →
CESC	OS	Median	All	0.908	0.838	.014	38	view →
KIRP	DFS	Tertile	All	0.973	0.854	.002	34	view →
ESCA	OS	Median	IV	0.222	0.698	.006	32	view →
ACC	OS	Median	IV	0.361	0.792	<.001	21	view →
CHOL	OS	Quartile	II,III,IV	0.088	0.650	.004	15	view →
LIHC	DFS	Median	All	0.189	0.380	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GO:0034374–COAD (OS)

Open the COAD breakdown →