Low-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Low-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLLT10, ZNF16, and PPP1R13L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLLT10 grouped by Low-density lipoprotein particle remodeling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MLLT10 →	+0.724	+1.382	.006	<.001	3	4
OESOPHAGUS	ZNF16 →	-0.748	-1.157	.005	<.001	3	4
LIVER	PPP1R13L →	-2.663	-1.655	<.001	<.001	3	4
LIVER	IQCE →	-1.802	-2.072	.002	<.001	3	4
LIVER	KLHL7 →	-0.611	-1.580	.001	<.001	3	4
LIVER	HARBI1 →	-0.445	-1.413	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLLT10 by Low-density lipoprotein particle remodeling activity — STOMACH

Explore this box plot interactively →