Low-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Low-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRLF1, TRIM22, and FEZ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Low-density lipoprotein particle remodeling activity versus CRLF1 in OVARY (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CRLF1 →	-2.320	-1.685	.005	.001	3	3
CNS	TRIM22 →	-3.393	-1.688	.007	<.001	2	4
SKIN	FEZ1 →	-2.260	-1.327	.001	.008	3	3
SKIN	ZNF646 →	-0.768	-1.327	<.001	.008	3	3
BLOOD_Leukemia	RCAN1 →	-1.875	-1.393	.005	<.001	3	3
KIDNEY	IRGQ →	-0.480	-1.694	.001	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034374 vs CRLF1 — OVARY

Explore this scatter interactively →