Glial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Glial cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TG, FBXW7, and KCTD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TG grouped by Glial cell apoptotic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TG →	+0.230	+0.204	<.001	.001	3	4
BLOOD_Myeloma	FBXW7 →	+0.372	+0.163	.006	.005	3	4
LUNG_NSCLC_LUAD	KCTD6 →	-0.115	-0.116	.002	.002	3	4
BREAST	OR2AK2 →	-0.225	-0.126	<.001	<.001	3	4
LUNG_NSCLC_LUSC	LCAT →	+0.298	+0.193	<.001	<.001	3	4
SKIN	PRKAR1A →	-0.177	-0.136	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TG by Glial cell apoptotic process activity — BONE

Explore this box plot interactively →